Acne is one of the most common dermatoses, especially among young people. The worldwide prevalence reaches up to 80% of young people aged 15 to 17 who have symptoms of acne, and the condition often persists into adulthood. In the pathogenesis of acne, in addition to pathological hyperkeratosis and inflammation, an important role is played by such factors as massive microbial contamination, species composition, biological properties of pathogens, in particular, their drug resistance. For the treatment of acne of moderate and severe severity, antibacterial drugs are used – tetracycline, erythromycin, doxycycline. These drugs have a bacteriostatic effect on Cutibacterium acnes by inhibiting the synthesis of bacterial proteins. Antibiotics for acne demonstrate antimicrobial and anti-inflammatory effects and act in two directions: they reduce the colonization of C. acnes and inhibit the production of inflammatory mediators associated with С. acnes. Side effects in antibiotic treatment are rare, but the main problem in their appointment is resistance, the frequency of which is increasing every year. The review part of the article presents the literature data of domestic and foreign authors on the formation of С. acnes resistance to antibiotic therapy in acne patients in the process of therapy evolution. Cause-and-effect relationships of the formation of resistance in the application of antibacterial drugs of various classes are described. The strategy and tactics of a doctor to limit the spread of C. acnes antibiotic resistance are considered. A special place in the article is given to the important role of benzoyl peroxide, clindamycin and the synergistic effect of the fixed combination of clindamycin / benzoyl peroxide in overcoming the resistance of С. acnes and achieving the effectiveness and safety of therapy. The second part of the article presents our own clinical observations of the effectiveness of the domestic combined preparation of the Klindavit Combo gel (clindamycin / benzoyl peroxide) in the treatment of patients with papulopustular acne who are on outpatient treatment by a dermatologist.

The research goal is to assess clinical dynamics and morphofunctional skin parameters of patients with facial allergic dermatoses on the background of combined topical therapy. Materials and methods. 45 patients with various facial allergic dermatoses in dry and sensitive skin took part in the research. The methods included anamnesis taking, poll, objective examination and assessment of morphofunctional parameters of skin, as well as estimation of life quality dynamic index (LQDI). Main results. After a course of treatment with 0,05% solution of alclometasone dipropionate inflammation of dermatosis ceased in 45 (100%) patients, itching and pains in 39 (86,7%) patients, but complaints about dryness and peeling of facial skin remained in 41 (91,1%) and 40 (88,8%) patients respectively. On the background of therapy including emollient Aflocream the above mentioned symptoms did not appear in 43 (95,6%) patients, wherein maximum effect was achieved in patients with allergic contact dermatitis - 14 (93,3%). After a course of topical therapy all patients showed statistically significant increase of epidermal moisture level, alongside with reduction of skin relief and degree of keratinization. During the assessment of LQDI a tendency to reduction of proportion of patients on whom the disease has a strong and extremely strong impact was noted in 10 patients (i.e. 22,2%), moderate influence - in 5 of them (11,45%), insignificant influence or its absence - in 30 (66,7%) people. Conclusion. Combined therapy including the use of a topical corticosteroid Afloderm and an emollient Aflocream showed good clinical efficiency in patients with facial allergic dermatoses. The efficiency is also confirmed with improvements in morphofunctional characteristics of patients’ skin on the background of therapy.