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Cutaneous ADRs are unavoidable and pose a major risk of drug therapy, modulated by several factors, resulting in significant morbidity and mortality. The aim of the study is to analyse various clinical patterns of cutaneous ADRs, to find its causative drugs and assess its causality and severity of reactions. Method: A prospective observational study, was conducted at tertiary care hospital, in Hyderabad for a period of 12 months. Patients presenting with CADRS to the department were included in this study. Causality and severity assessment was done by using WHO UMC system and Modified Hartwig and Siegel scale respectively. Results: Total 58 patients were enrolled. Mean age group was 40.6 years (range 11 to 83 yrs). Out of them, 32 were males and 26 were females. The most commonly manifested CADRs was Maculopapular rash (24.13%) followed by FDE ( 22.4%) and Urticaria (10.34%). About 8 (13.79%) cases were found with severe CADRs. Few cases of Hand -Foot Syndrome, Lichenoid Drug Eruptions were also noted. The most common suspected drug group was Antimicrobials (29.13%) and NSAIDS (29.3%). Most common suspected drug was ciprofloxacin and diclofenac. Conclusion: The health care system can promote spontaneous reporting of cutaneous ADRs to Pharmacovigilance centre's for ensuring safe drug use and patient care.