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METHODSThis was a cross sectional study carried out in the Department of surgery of a tertiary health care centre during the one year period i.e. August 2018 to August 2019 so during this period there were 60 patients with ABSTRACT Background: Insulin being a growth factor was proved to stimulate angiogenesis, collagen formation, matrix formation and granulation tissue proliferation in several preclinical studies. The objective was to study effectiveness of topical insulin on healing of diabetic ulcers at tertiary health care centre. Methods: This was a cross sectional study carried out in the Department of surgery of a tertiary health care centre during August 2018 to August 2019 so during this period there were 60 patients. Group A was given topical insulin application. Group B was given saline application. The statistical analysis was done by using SPSS 24.0 version and un-paired t-test and chi-square tests are applied as test of significance. Results: Average time required for granulation tissue to appear (mean±SD) was significantly less in group A as compared to Group B (p<0.001, df=58, t=5.87); Average surface area of wound (mm 2 ) at day 6th day was significantly less in group A (p<0.05, df=58,t=3.98); average depth of the wounds (mm) at day 6th day was significantly less in Group A as compared to in Group B (p<0.001, df=58, t=4.92). Conclusions:The topical application of insulin is significantly associated with fastening of wound healing in the diabetic ulcer.

Background: Worldwide, burn injury is a problem and cause intense pain, biological dressings like collagen as it forms physiological interface prevents infection effective for burn wound healing. The objective of the study was to study of collagen dressing versus conventional dressings in burns at tertiary health care centre. Methods: This was a cross sectional study carried out in the Department of Surgery during September 2018 to September 2019. Out of 50 patients, 25 were enrolled to collagen treatment group (group A) and remaining into conventional treatment group i.e. (group B). The statistical analysis was done by unpaired t-test and chi-square test. Results: Average less time required for granulation tissue to appear p<0.001, df=48, t=4.56); average less time requires for sterile wound swab culture (weeks) (p<0.05, df=48, t=3.45); less discomfort score (0-10) (p<0.001, df=48, t=6.78); less dressing removal pain score (0-10) (p<0.0001, df=48, t=9.87); less average time required for complete healing (days ) (p<0.001, df=48, t=7.79). Conclusions: It can be concluded that collagen dressings were superior to conventional dressing in wound healing of burns.

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