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Purpose: To estimate effectiveness and safety of innovative dressings in local conservative therapy of children with burns.Materials and methods: the study was based on the results of using innovative dressings in children aged 1–4 years with I–II–III degree skin burns occupying 1–10% of body surface (b. s.). Routine methods of examination such as follow-up visual examination of wounds, temperature monitoring, follow-up microbiological control of burn wounds determining sensitivity to antimicrobials were used; duration of spontaneous epithelization of the burnt areas, lack or availability of allergic and other adverse reactions were determined.Results and conclusions: effectiveness and safety of using therapeutic dressings in patients with thermal injuries are verifed using clinical cases. Good therapeutic effect is confrmed when a line of dressings is combined depending on the phase of the wound process and tissue affection depth with hot liquid. Possible complications in the form of allergic reactions are found (contact dermatitis, in particular). Methods of their prevention or adequate local conservative therapy are recommended. Results of using LikoTul Ag+, PoviTex, JelleSorb Ag + Tube and AquaColl Ag+ dressings display their effectiveness and safety.

In the blood of children (n=16) with large thermal skin burns (> 20% of total body surface), luminol-dependent chemiluminescence (CL) of neutrophils stimulated with phorbol-12-myristate-13-acetate (PMA) and myeloperoxidase (MPO) activity in neutrophils and plasma were assayed in the early period (1-7 post-burn days). PMA-stimulated neutrophils in thermally injured patients produced higher CL than those in a reference group of healthy children (n=24), p<0.01. MPO activity was elevated in neutrophils and plasma in 40% and 57% of patients' blood samples, respectively. The albumin fraction isolated from plasma of burned patients enhanced the PMA-stimulated CL response of blood samples from healthy volunteer. Our results suggest that the acute inflammatory response induced by thermal injury involves activation of neutrophils and is accompanied by MPO release into the plasma. MPO-mediated modification of serum albumin induces its capacity to prime neutrophils and thus to enhance further inflammatory reaction.

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