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Objective: The aim of the study was a quantitative assessment of the effects of calcium antagonist on regional systolic and diastolic myocardial function in patients (pts) with systemic sclerosis (SSC), using pulsed wave Doppler myocardial imaging (PW-DMI). Method: Thirty-two female subjects: 17 pts with SSC (mean age 52.5 ± 8.7 years, with an onset of SSC > 5 years; SSC group) and 15 healthy subjects (mean age 51.2 ± 7.7 years; C group) were studied. In all subjects baseline echocardiography study was performed. Regional myocardial function, was obtained from apical approach, with PW-DMI sample volume within any left ventricular (LV) segment at basal and medium level. In each adequately visualized segment we calculated myocardial velocities (m.v.) of systolic (S), early (E) and late (A) diastolic waves and their ratio E/A -index of regional diastolic function. After the initial study, pts in the SSC group were treated with calcium antagonist for a period of six months and after treatment period regional myocardial function was evaluated again. Results: Baseline value of regional diastolic function of basal and medium LV segments was significantly lower in SSC than in C group (E/A: 0.93 ± 0.33 vs 1.52 ± 0.31. P<0.001 and 0.87 ± 0.32 vs 1.47 ± 0.30, P<0.001), as well as regional systolic function (P<0.001 both). After six months treatment period with calcium antagonist in the SSC group regional diastolic function of basal LV segments improved (E/A from 0.93 ± 0.33 to 1.08 ± 0.35, P<0.01) as well as of medium LV segments (E/A from 0.87 ± 0.32 to 0.98 ± 0.28, P<0.05); regional systolic function of basal LV segments increased from 8.5 ± 3.5 to 9.5 ± 3.0 cm/s, P<0.05, and of medium LV segments from 7.8 ± 3.2 to 8.5 ± 2.9 cm/s, NS. Conclusion: Quantitative analysis by PW DMI showed that pts with SSC have impaired regional systolic and diastolic myocardial function. Six months treatment with calcium antagonist in pts with SSC induced favorable modification of regional myocardial function, expressed through significant increased of basal S m.v. and ratio E/A of basal and medium left ventricular segments. Myocardial remodeling is an important predictor of risk of death in end stage chronic renal failure. The aim of study was to investigate cardiac remodeling peculiarities in patients with chronic renal failure(CRF) treated with dialysis. Methods: 32 patients with end stage of CRF at early treatment with hemodialysis were enrolled. The underlying diseases were glomerulonephritis (n=22), diabetes mellitus (n=7), amyloidosis(n=3). The duration of symptoms associated with CRF end stage was 2.5±1.9 years. Echocardiography, serum creatinine, albumine, hemoglobine, hematocrit, parathyroid hormone (PTH) concentrations were evaluated in all patients at the next hours after hemodialysis. Concentric left ventricular hypertrophy was detected by echo in 27 patients (84%) and in 2 patients (6.2%) eccentric hypertrophy was observed. Mean serum values of creatinine, parathyroid hormone (PTH) were differed from normal values. Left ventri...