Cancer is a complex and serious illness. The modern treatment and techniques treat succeed on many types of diseases unfortunately there is no appropriate medicine for every types of Cancer. The Siddha Medical System correlates the diseases like Puttru Noi, Vipprudhi, Kandankirandhi, Kaddi, Raajapilavai, Thurmaangisam, Maamisa makotharam, Sathai adaippu and Silandhi with the signs and symptoms of Cancer under the Modern Medical Systems. In Siddha Medicine, medicinal plants play an important role in treating many diseases, though animal products and minerals also used in drugs.  Rasa Ganthi Meluku, Nanthimai, Rasaparpam, Vangaparpam, Senkoddai ghee, Sengoddai illagam etc are some of the important medicine mentioned in the Siddha Medical texts to treat Cancer. In this research we identify and discuss the raw materials which are used to cure the diseases related to Cancer in modern medicine. Sesame seed is mostly noted (3.15%) in the above important medicines. Longer pepper used in 2.36%, Garlic, Ginger, Chebulic myrobalan and Black cummin used in 2.10% of important medicines. Mercury is mostly noted (12.77%) in the above important medicines. Sulphur used in 10.64%, Arithaaram and Inthuppu used in 7.45% of important medicines. Ghee is mostly noted (40.91%) in the above important medicines. Cow milk used in 27.27%, and goat milk used in 9.09% of important medicines.