The authors analyze the bibliographic information on ecological developments in Donbass for 2000–2022. With the subject headings of the bibliographic index, they follow the trends in ecotechnologies, scientific research and implementation of environmental protection methods and optimization of industrial region’s environments. They emphasize the value of targeted scientific research as the key source of science popularization and public ecological monitoring. They review research, technological and socially important undertakings that in aggregate contribute to achieve all possible harmonization of human existence in the transformed natural ecosystems. The botanical ecological monitoring of natural environments in Donbass has been the only and unique large-scale continuing experiment of independent expertise of region’s natural ecosystems during the social and political conflict (2014–2022). The research project in Donbass is not only the intellectual property object but also the source of ecological education, in particular, owing to the bibliographic analysis and direct community outreach.