Modern immunological and molecular genetic studies showed that tuberculosis is accompanied by an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes. T allele and homozygous TT genotype of T-330G polymorphism in the IL2 gene, T allele and TT genotype of C-590T polymorphism in the IL4 gene, and CC genotype of A-1188C polymorphism in the IL12B gene are immunogenetic factors that have protective activity against susceptibility to pulmonary tuberculosis. Susceptibility to tuberculous infection is associated with A1A2 genotype of the polymorphic region +3953 A1/A2 in the IL1B gene; G allele and TG and GG genotypes of T-330G polymorphism in the IL2 gene; C allele and CC and CT genotypes of C-590T polymorphism in the IL4 gene; and AC genotype of the polymorphic region A-1188C in the IL12 gene.

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Subject. The value of a firm is an unbiased and reliable measure of operations and strategic performance of an enterprise. Objectives. The study analyzes a combination of approaches based on the book and market values as part of the information asymmetry theory, which points out the comprehensive integrated indicator, such as a firm's value as an unbiased and the most understandable metric for stakeholders, shareholders, would-be investors and managers. Methods. The study is based on methods of induction, deduction and general cognition, methods of logic, statistical and correlation analyses. Results. It is advisable to reduce the information asymmetry for principals and agents by updating the Economic Value Added (EVA) and derivative indicators, such as CFROI, CVA, RCF and EM, which are integrated into consolidated income, earnings before taxes and structure of capital owned by subsidiaries and associates and share of capital invested in the development of property portfolios of corporations. Subsidiaries and associates contribute to the consolidated net income, being financially accountable for the capital involved. Conclusions and Relevance. To forecast the value of a firm, economic-mathematical modeling is advisable, since it will ensure an unbiased evaluation of the firm’s position within a three to five year time horizon and help to reduce the information asymmetry, which requires special tools to substantiate the increment in EVA and corporate capitalization. The ultimate objective of research provides for an unbiased integrated value, such as corporate value of a business, which decreases the information asymmetry for principals and agents.

The development of market relations in the construction complex of Russia requires the solution of problematic issues not only of a regional nature, but also of a federal level. This is due to the improvement of the methodology for the analysis of economic indicators in construction. Based on the study of modern theoretical and conceptual approaches and methodological developments in construction practice for the analysis of production, business and financial activities of construction corporations, an author’s concept of a prognostic analysis of the development of the region’s building complex with detailed indicators and analytical procedures for their step-by-step solution is proposed. The achievement of the research goal has led to the use of methods of induction, deduction, and general scientific knowledge. The article also uses correlation and regression analysis, analysis of variance and coefficient analysis as the basis of the author’s, system-process approach within the framework of the research problem under consideration. The real advantage of modern information and communication technologies used in the forecast analysis, which provides an opportunity for a more objective formalized assessment of the modern development directions of the construction complex of a separate region and Russia as a whole, has been proved.