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Determining cytokinemia role in the destructive processes of the periodontal complex gives new opportunities to the development and subsequent implementation of practical methods for chronic periodontitis diagnosis, justifies including pathogenetic drugs that inhibit the secretion of pro-inflammatory mediators in treatment regimens. The aim of the study is to evaluate the dynamics of cytokine profile indicators and identify their correlation with the local status of periodontal tissues in animals with experimental periodontitis. Materials and methods. The study enrolled 65 white outbred rats weighing 180±20 g. The authors reproduced the model of experimental periodontitis according to K.D. Shkolnaya, V.G. Atrushkevich method (patent RU No. 2625295, December 07, 2017). The cytokine profile was assessed by pro-inflammatory and anti-inflammatory cytokine levels, determined by enzyme-linked immunosorbent assay, Bender MedSystems reagent kit. Local status of periodontal tissues was assessed according to the degrees of gingival hemorrhage, dental mobility and depth of periodontal pockets with a button-shaped and modified periodontal probes. Results. During the experimental periodontitis modeling, a high level of cytokinemia was determined. It destructively effects the periodontal connective tissue matrix, which was confirmed by an increase in the depth of periodontal pockets, gingival hemorrhage and dental mobility. A strong correlation between a high level of cytokinemia and local destructive changes in periodontal tissues was determined. This fact emphasized the conjugation of these pathophysiological mechanisms. Conclusion. Defined disorders of physiological balance in the cytokine balance necessitate the use of pathogenic drugs, as they have an inhibitory effect on the synthesis of pro-inflammatory cytokines and prevent further destruction of the periodontal complex. Changes in the cytokine profile indicate inflammation process, and a decrease in the level of cytokinemia indicate the resolution of infection and can be considered a criterion for the effective treatment.