The problem of rational antibiotic therapy of pneumonia is one of the most relevant in modern medicine. So far, a large number of the factors have been identified that determine the optimal quality of antimicrobial therapy: the maximum effectiveness with the lowest toxicity of drugs should be combined with their proper cost. In order to study the clinical efficacy and therapeutic tolerability of the drug class of macrolides, clarithromycin for parenteral use in the treatment of patients with community−acquired pneumonia, 20 patients were examined. All the patients had clinical symptoms of severe infectious lesions of the lower respiratory tract. The complex therapy (detoxification, mucolytic drugs, multivitamins, metabolites) included "Clarithromycin−MB", which was administered intravenously for 60 minutes at a dose of 500 mg 2 times a day for 7−10 days. The clinical effectiveness of antibacterial therapy was assessed by the dynamics of the activity of the inflammatory process in the lungs. For this purpose, the following clinical and laboratory parameters characterizing the activity of the inflammatory process (temperature response, tachycardia, respiratory rate, leukocytosis, number of immature granulocytes, change in erythrocyte sedimentation rate), severity of pain, radiological changes in the lungs were determined. Macrolide "Clarithromycin−MB" in a parenteral form is a highly effective antibacterial drug for the treatment of community−acquired pneumonia with severe course. Positive dynamics of clinical manifestations of the disease was observed on the third day from the beginning of therapy. "Clarithromycin−MB" has good therapeutic tolerability, the dosage regimen allows to maintain the required concentration in the site of inflammation, which affects the clinical and bacteriological efficacy of treatment of the patients with community−acquired pneumonia. Key words: community−acquired pneumonia, macrolides, "Clarithromycin−MB".

The article presents the epidemiological and clinical data of the modern course of chickenpox. A high incidence among adults with a bright manifestation of the clinical picture was shown. Recurrent episodes of chicken pox were marked. The modern course of varicella in Ukraine is characterized by an increase in the incidence among the adult population. Infection is manifested by a long prodromal period, a pronounced intoxication syndrome, lymphadenopathy, and an abundant polymorphic rash. At the same time, the rash had a pustular character in 54.3 % of patients; exanthema was observed with scleritis and conjunctivitis in 45 % of cases. There are repeated cases of chickenpox, the interval between these episodes ranged from 5 to 12 years. Taking into account the epidemiological situation in the country it remains relevant to study main features of the course of chickenpox in individuals against the background of pulmonary tuberculosis, depending on the age and duration of the underlying disease.