Isoxazole derivatives R 0240Synthesis and Antinociceptive Activity of Pyrazolyl Isoxazolines and Pyrazolyl Isoxazoles. -The title compounds are synthesized using 1,3-dipolar cycloaddition of nitrile oxides, generated in situ from pyrazolyl hydroximoyl chlorides (II), with dipolarophiles (III) or (V). Dicarbethoxyisoxazoles (VIa), (VIb) and (VIIIa) exhibit the highest antinociceptive activity. -(KARTHIKEYAN, K.; SEELAN, T. V.; LALITHA, K. G.; PERUMAL*, P. T.; Bioorg. Med.
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