Objectives:  To evaluate the frequency of reactive and clonal thrombocytosis based on age, sex, clinical findings, and severity of thrombocytosis. We also highlight the determination of hematological parameters for the diagnosis of these disorders required the management of thrombocytosis to reduce the morbidity and mortality rate. Methods: This descriptive experimental study was conducted in the Diagnostic and Research laboratory, Peoples University of Medical and Health Sciences, Nawabshah and department of Pathology, from July 2017 to June 2018. Total 325 patients including 260 patients with reactive thrombocytosis and 65 patients with clonal thrombocytosis, their age ranged between 12 and 45 years and 35 to 68 years were selected. The male to female ratio were 1.5:1 and 2.5:1 while clinical history and clinical examination were noted. The blood samples were taken from all these patients for the analysis of hematological parameters by a hematological analyzer (Nihon Corden) and an iron profile performed for assessment of iron status to confirm the diagnosis of iron deficiency anemia. The examinations of peripheral blood smears and bone marrow smears in the case of clonal thrombocytosis seen in chronic myeloid leukemia essential for the diagnosis. Results: The mean ages and male to female ratio among 325 patients with reactive and clonal thrombocytosis were 28.5 + 16.5, 51.5 +16.5 and 1.5:1, 2.5:1 ratio were found in this study. The mild to moderate thrombocytosis were found in reactive thrombocytosis while moderate to severe thrombocytosis was detected in patients with chronic myeloid leukemia. Conclusions: The frequency of thrombocytosis was higher in clonal thrombocytosis than the reactive type.

Aim: To determine the side effects of skin whitening creams in a tertiary care facility. Methodology: The current cross-sectional study was conducted at the department of dermatology, Peoples University of Medical & Health Science for Women Nawabshah (PUMHSW), Sindh, Pakistan from January 2019 to July 2019. A total of 140 consecutive patients were included in the study matching the inclusion criteria. All the demographic clinical variables and follow-up data were recorded on a proforma designed for the study, the data collected were statistically analyzed and the results were tabulated. Results: In this study we observed various side effects in patients who used whiting creams. Redness showed in 81 patients (57.85%), flushing in 86 patients (61.42%), sensitivity in 99 patients (7.14%), acne in 52 patients (37.14%), thinning of skin in 77 patients (55%), pigmentation in 67 patients (47.85%),telangiectasiain 43 patients (30.71%), wrinkles in 33 patients (23.57%), and hirsutism in 44patients (31.43%). Conclusion: We concluded that whitening creams used in our facilityare strongly associated with several cutaneous side effects.