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Receptor binding activity X 0280Identification of Putative Metabolites of Docosahexaenoic Acid as Potent PPARγ Agonists and Antidiabetic Agents. -A series of putative metabolites of docosahexaenoic acid (DHA) is prepared and their activity as PPARγ activators or antidiabetic agents is studied. (I) is a fourfold stronger PPARγ activator than pioglitazone and (II) shows antidiabetic activity in animal models without producing undesirable effects such as obesity and hepatotoxicity. -(YAMAMOTO*, K.; ITOH, T.; ABE, D.; SHIMIZU, M.; KANDA, T.; KOYAMA, T.; NISHIKAWA, M.; TAMAI, T.; OOIZUMI, H.; YAMADA, S.; Bioorg. Med. Chem. Lett. 15 (2005) 3, 517-522; Inst. Biomater. Bioeng., Med. Dent. Univ., Chiyoda, Tokyo 101, Japan; Eng.) -M. Bohle 26-169

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