No abstract

Histologic analysis of squamous cell carcinoma of the lower alveolus shows 2 basic patterns of tumor spread in relation to the mandible: an infiltrative one and an expansive one. While the tumor invades the mandible by destroying the bone or through cortical defects of some spaces in the infiltrative form, the tumor does this only by eroding the bone in the expansive form, in which the degree of bone resorption seems to be proportional to tumor advancement. A comparison between radiologic and histologic features discloses that the radiologically detected bone defects are not necessarily correlated with the patterns of bone involvement. However, most lesions with erosive bone defects show the expansive pattern histologically, and the extent of the radiologically detected bone defect is roughly in accordance with the histologic extent of bone involvement. These results lead us to believe that some squamous carcinoma of the lower alveolus could be treated successfully without sacrificing the continuity of the mandible.

No abstract

A recent study showed that carbon nanohorns (CNHs) have biocompatibility and possible medical uses such as in drug delivery systems. It was reported that some kinds of carbon nanomaterials such as carbon nanotubes were useful for bone formation. However, the effect of CNHs on bone tissue has not been clarified. The purpose of this study was to evaluate the effect of CNHs on bone regeneration and their possible application for guided bone regeneration (GBR). CNHs dispersed in ethanol were fixed on a porous polytetrafluoroethylene membrane by vacuum filtration. Cranial defects were created in rats and covered by a membrane with/without CNHs. At two weeks, bone formation under the membrane with CNHs had progressed more than under that without CNHs and numerous macrophages were observed attached to CNHs. At eight weeks, there was no significant difference in the amount of newly formed bone between the groups and the appearance of macrophages was decreased compared with that at two weeks. Newly formed bone attached to some CNHs directly. These results suggest that macrophages induced by CNHs are related to bone regeneration. In conclusion, the present study indicates that CNHs are compatible with bone tissue and effective as a material for GBR.

A new laminoplasty of the cervical spine has been developed using preserved ligaments as a tension-band. The laminae were enlarged in an open-door fashion and spacers inserted to maintain the spinolaminoligamentous complex intact. The stretched ligaments exerted a tension-band effect on the spacers and stabilised them so that neck movements could be started as soon as bleeding stopped. The spacers were iliac grafts, or were made of a bioactive ceramic which proved more satisfactory. The results of 102 cases with ceramic spacers showed an average preservation of preoperative movement between C2 and C7 to be 79% in cervical spondylotic myelopathy and 67% in ossification of the posterior longitudinal ligament at 3 years after operation. No spacer became displaced. CT showed new bone formation in the lamina-ceramic gap in 59% of the spacers used in cervical spondylotic myelopathy by sixth months and in 63% in cases of ossification of the posterior longitudinal ligament by the third month. Neurological recovery was comparable to that after other types of laminoplasty, but the new method allows better function of the neck and more new bone formation around the spacers.