To investigate antidiabetic efficacy of Fenugreek (F) and Termis (T) seeds aqueous extracts in streptozotocine induced diabetes in rats. Experimental diabetes was induced by intraperitoneal injection of a single dosage of STZ (50 mg/kg, i.p.). Adult male rats were divided into five groups; (1) normal control, (2) diabetic control, (3) diabetic-F supplement (1 g/kg b. wt.), (4) diabetic-T supplement (1 g/kg b. wt.) and (5) diabetic- mixture (M) supplement (1 g/kg b. wt.) of each seed extracts concurrently for 30 days. The decreased insulin, plasma GSH, GST, CAT, as well as liver and muscle glycogen content and increased serum glucose, total lipids, triglycerides, total cholesterol, creatinine, urea, uric acid, AST, ALT, and ALP were the salient features recorded in diabetic control rats. This study showed that the regular intake of the T. foenum graecum, L. albus seeds water extract and their mixture can improve antioxidant status and considered as an effective agent in modulating the alterations due to diabetes.

No abstract

The present study was carried out to investigate the protective effects of fresh carrot juice on Hepato renal injuries induced by a single intraperitoneal injection of cisplatin (CP) (5 mg/kg). The AST, ALT activities, and the levels of creatinine, urea were significantly (P < 0.05) increased in the serum of CP-treated rabbits (positive control) as compared to the normal rabbits (negative control). in contrast, Triglycerides and cholesterol concentrations were significantly decreased in the serum of CP-treated rabbits as compared to the normal rabbits. A dose of 5ml /kg body weight of fresh carrot juice was orally administered for 4 consecutive days before (CP) injection and 3 consecutive days after the (CP) injection reduced activities of AST, ALTand serum urea, serum creatinine levels which were altered by (CP), and succeeded in restoring of Triglycerides, cholesterol concentrations significantly to the normal range. On the other hand, histopathological Hepato renal tissue damage mediated by (CP) was greatly ameliorated by fresh carrot juice treatment. It was concluded that fresh carrot juice represents a potential therapeutic option to protect against (CP) Hepatorenal injuries commonly encountered in clinical practice.