Background & Objective: Fertility is important in developing personality, and infertility is a disorder that often bears unintended and sometimes untreatable consequences for couples. As an element of personal features, mental health is often related to marital satisfaction. In this study, the correlation between mental health and marital satisfaction is investigated in infertile couples referring to the Kosar Infertility Center of Urmia, Iran. Materials & Methods:This cross-sectional study was performed on 186 infertile couples referred to Kosar Infertility Center, Iran. They were randomly selected in 2018. The data were collected using General Health Questionnaire and Enrich Marital Satisfaction Questionnaire completed by the participants. In the present study, to conduct data analysis, SPSS version 25.0 was used along with inferential and descriptive statistics.Results: Idealistic distortion had a significant relationship with mental health in infertile couples (P=0.015). Moreover, leisure activities (P=0.043) and financial management (P=0.017) had a significant inverse relationship with mental health in infertile couples. Conclusion:According to the findings, based on the association between marital satisfaction and mental health, mental health can be improved by solving marital problems and enhancing the satisfaction of infertile couples. Hence, the health status of families is improved, denoting the considerable contribution of family counseling centers.