Light transmission of Laguerre-Gaussian vector vortex beams in different local regions in mouse brain tissue is investigated. Transmittance is measured in the ballistic and diffusive regions with various polarizations states and orbital angular momentums (OAM). The transmission change observed with structured light other than linear polarization is attributed to chiroptical phenomena from the chiral brain media and the handedness of the light. For instance, classically entangled beams showed higher transmittance and constant value dependency on OAM modes than linear modes did. Also, circular polarization beam transmittance showed strong increase with topical charge OAM ( ℓ), which could be attributed to chiroptical effect.