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The metabolite profiles and distributions of procyanidin B2 were qualitatively described using UPLC-DAD-ESI-IT-TOF-MSn without help of reference standards, and a possible metabolic pathway was proposed in the present study. Summarily, 53 metabolites (24 new metabolites) were detected as metabolites of procyanidin B2, and 45 of them were tentatively identified. Twenty seven metabolites were assigned as similar metabolites of (−)-epicatechin by scission of the flavanol interflavanic bond C4–C8, including 16 aromatic metabolites, 5 conjugated metabolites, 3 ring-cleavage metabolites, and 2 phenylvalerolactone metabolites. Additionally, 14 metabolites were conjugates of free procyanidin B2, comprising 9 methylation metabolites, 8 sulfation metabolites, 5 hydration metabolites, 2 hydroxylation metabolites, 1 hydrogenation metabolites, and 1 glucuronidation metabolites. The results of metabolite distributions in organs indicated that the conjugated reaction of free procyanidin B2 mainly occurred in liver and diversified metabolites forms were observed in small intestine. The metabolic components of procyanidin B2 identified in mice provided useful information for further study of the bioactivity and mechanism of its action.

Objectives There are more than 300 million smokers in China. This study aimed to evaluate the rate of smoking cessation, smoking relapse and related factors in middle-aged and older smokers in China. Methods We performed a secondary analysis of data from China Health and Retirement Longitudinal Study (CHARLS) that recruited a nationally representative sample of adults aged 45 and older. Participants were 3708 smokers in 2011 who completed two waves of follow-up interviews in 2013 and 2015. Self-reported quit and relapse rates at follow-ups were estimated. Multiple logistic regressions were conducted to identify factors associated with smoking cessation and relapse. Results The overall quit rate was 8.5% (95% CI 7.7%-9.5%) at the 2-year follow-up in 2013, and 16.6% (95% CI 15.5%-17.9%) at the 4-year follow up. Smoking cessation in 2013 was associated with not living in the northeast region (p = 0.003), fewer cigarettes smoked daily (p <0.001), and longer time to the first cigarette in the morning (p<0.001). Smoking cessation in 2015 was associated with older age (p = 0.049), smoking initiation at age �20 years (p<0.001), longer time to the first cigarette in the morning (p<0.001), and self-perceived poor health (p<0.001). Of the 317 participants who stopped smoking in 2013, 13.3% (95% CI 9.9%-17.5%) relapsed by 2015. Smoking relapse was associated with younger age (p = 0.025), shorter time to the first cigarette in the morning (p = 0.003), and self-perception of not poor health (p = 0.018). Conclusion The overall quit rate was 8.5% at the 2-year follow up, and 16.6% at the 4-year follow up in the middle-aged and older smokers, but 13% of quitters returned to smoking in two years.

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The assessment systems for green building have been developed and implemented for decades. Well-known systems include the U.S. system LEED, the U.K. system BREEAM, the Canadian system GB tools, and the Japanese system CASBEE. These systems will be discussed and compared together with Taiwan’s EEWH system. Each assessment system may contain a different set of evaluation items to evaluate the sustainability level of a building project. Contrarily, the assessment system for green civil infrastructure projects is rarely discussed and developed globally. In Taiwan, studies have been conducted to develop a new assessment system with some reasonable key indicators and evaluation items, serving as the tool to evaluate the sustainability level of a green civil infrastructure project. In this paper, the authors studied and summarized different key indicators and evaluation items, and made comparisons among some major assessment systems for both green building and green civil infrastructure projects. Based on the comparison of the various assessment systems, it is found that greenery, recycling of materials, water conservation, carbon emission reduction, and energy saving are considered in both green building and green civil infrastructure assessment systems. Nevertheless, external building structure, energy consumption, healthy air and temperature, illumination of the indoor environment, rainwater recycling, and underground reservoirs are considered only in green building assessments, but not in green civil infrastructure assessments. Moreover, durability, benefits, landscape, humanities, culture, and creativity, which are discussed adequately in green civil infrastructure assessments, are not highlighted in green building assessments. In addition, two construction projects in Taiwan, one green building project and one green civil infrastructure project, are presented to exemplify sustainability practices and assessments.