The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highly specific toxicity against human oral squamous cell carcinoma cell lines, with much lower toxicity against human oral keratinocytes, as compared with various anticancer drugs. QSAR analysis suggests the possible correlation between their tumor-specificity and three-dimensional molecular shape. Condensed tannins in the tea extracts inactivated the glucosyltransferase enzymes, involved in the biofilm formation. Lignin-carbohydrate complexes (prepared by alkaline extraction and acid-precipitation) and crude alkaline extract of the leaves of Sasa species (SE, available as an over-the-counter drug) showed much higher anti-HIV activity, than tannins, flavonoids and Japanese traditional medicine (Kampo). Long-term treatment with SE and several Kampo medicines showed an anti-inflammatory and anti-oxidant effects in small size of clinical trials. Although the anti-periodontitis activity of synthetic angiotensin II blockers has been suggested in many papers, natural angiotensin II blockers has not yet been tested for their possible anti-periodontitis activity. There should be still many unknown substances that are useful for treating the oral diseases in the natural kingdom.

We have proposed a new approach to search for axion dark matter with an optical ring cavity [Phys. Rev. Lett. 121, 161301 (2018)]. The coupling of photons to axions or axion-like particles makes a modulated difference in the phase velocity between left-and righthanded photons. Our method is to measure this phase velocity difference with a ring cavity, by measuring the resonant frequency difference between two circular polarizations. Our estimation shows that the sensitivity to axion-photon coupling constant gaγ for axion mass m 10 −10 eV can be improved by several orders of magnitude compared with the current best limits. In this paper, we present the principles of the Dark matter Axion search with riNg Cavity Experiment (DANCE) and the status of the prototype experiment, DANCE Act-1.

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Dark matter Axion search with riNg Cavity Experiment (DANCE) was proposed to search for axion dark matter [Phys. Rev. Lett. 121, 161301 (2018)]. We aim to detect the rotation and oscillation of optical linear polarization caused by axion-photon coupling with a bow-tie cavity. DANCE can improve the sensitivity to axion-photon coupling constant gaγ for axion mass ma < 10−10 eV by several orders of magnitude compared to the best upper limits at present. A prototype experiment DANCE Act-1 is ongoing to demonstrate the feasibility of the method and to investigate technical noises. The optics was assembled and the performance of the cavity was evaluated. The first 12-day observation was successfully performed in May 2021. We reached 3 × 10 − 6 rad / Hz at 10 Hz in the one-sided amplitude spectral density of the rotation angle of linear polarization.