Newly identified cyclic sulfoxides-garlicnins K 1 (1), K 2 (2), and H 1 (3)-were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin H 1 (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K 1 and K 2 , 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H 1 , 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.

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Isolation and structure elucidation of the new cyclic sulfoxides (I)—(III) are described.