We have performed a high-resolution angle-resolved photoelectron spectroscopy study on the newly discovered superconductor Ba0.6K0.4Fe2As2 (Tc = 37 K). We have observed two superconducting gaps with different values: a large gap (∆ ∼ 12 meV) on the two small holelike and electron-like Fermi surface (FS) sheets, and a small gap (∼ 6 meV) on the large hole-like FS. Both gaps, closing simultaneously at the bulk transition temperature (Tc), are nodeless and nearly isotropic around their respective FS sheets. The isotropic pairing interactions are strongly orbital dependent, as the ratio 2∆/kBTc switches from weak to strong coupling on different bands. The same and surprisingly large superconducting gap due to strong pairing on the two small FSs, which are connected by the (π, 0) spin-density-wave vector in the parent compound, strongly suggests that the pairing mechanism originates from the inter-band interactions between these two nested FS sheets.

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Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.

T he response of a material to external stimuli depends on its low-energy excitations. In conventional metals, these excitations are electrons on the Fermi surface-a contour in momentum (k) space that encloses all of the occupied states for non-interacting electrons. The pseudogap phase in the copper oxide superconductors, however, is a most unusual state of matter 1 . It is metallic, but part of its Fermi surface is 'gapped out' (refs 2,3); low-energy electronic excitations occupy disconnected segments known as Fermi arcs 4 . Two main interpretations of its origin have been proposed: either the pseudogap is a precursor to superconductivity 5 , or it arises from another order competing with superconductivity 6 . Using angle-resolved photoemission spectroscopy, we show that the anisotropy of the pseudogap in k-space and the resulting arcs depend only on the ratio T/ T * (x), where T * (x) is the temperature below which the pseudogap first develops at a given hole doping x. The arcs collapse linearly with T/ T * (x) and extrapolate to zero extent as T → 0. This suggests that the T = 0 pseudogap state is a nodal liquid-a strange metallic state whose gapless excitations exist only at points in k-space, just as in a d-wave superconducting state.In Fig. 1a,b we show data for a slightly underdoped sample of Bi 2 Sr 2 CaCu 2 O 8+δ (Bi2212) with a transition temperature T c = 90 K, for the superconducting state at 40 K, and the pseudogap phase at 140 K. The energy distribution curves (EDCs) at the Fermi momentum k F , which have been symmetrized 4 to remove the effects of the Fermi function on the spectra. k F is determined by the minimum separation between the peaks in the symmetrized spectra along each momentum cut. Fifteen momentum cuts were measured, as shown in Fig. 1e. Details of the symmetrization procedure are explained in the Methods section. The difference between the spectra in the two states is apparent: sharp spectral peaks are present in the superconducting state, indicating longlived excitations, and the superconducting gap vanishes only at points in the Brillouin zone, known as nodes; on the other hand, the spectra in the pseudogap phase are much broader, indicating short-lived excitations. Although a pseudogap is seen in cuts 1-7, substantial parts of the Fermi surface, cuts 8-15, show spectra peaked at the Fermi energy, indicating a Fermi arc of gapless excitations.The gap size can be estimated as half the peak-to-peak separation in energy. A more quantitative estimate is obtained by using a simple phenomenological function to describe the spectral lineshapes 7

Photoemission spectra of Bi2Sr2CaCu2O 8+δ reveal that the high energy feature near (π, 0), the "hump", scales with the superconducting gap and persists above Tc in the pseudogap phase. As the doping decreases, the dispersion of the hump increasingly reflects the wavevector (π, π) characteristic of the undoped insulator, despite the presence of a large Fermi surface. This can be understood from the interaction of the electrons with a collective mode, supported by our observation that the doping dependence of the resonance observed by neutron scattering is the same as that inferred from our data.