As for the question why the efficacy of DDS can extend over several diseases of exudative but non-infectious such as Herpes dermatitis, Erythema elevatum diutinum, Impedigo in sublayer of Stratum corneum, Schonlein-Henoch type anaphylactic Purpura, Gougerot-Ruiter type allergic Angitis in corium, and Parapsoriasis by daily dosage of 50-150 mg of DDS could not be explained before Katabira, et al, of Japan dermatological field found out a clue to discovery of its inhibitory effect on Carrageenin-induced rat acute edemas, 2, .

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