Takahiro Yabuuchi scite author profile

A number of arylbiurets were prepared and evaluated as antiinflammatory and analgesic agents by using the carrageenan paw edema and acetic acid stretching tests. Among them, the antiinflammatory activity of 1,3-dimethyl-5-phenylbiuret (7), 1-ethyl-3-methyl-5-phenylbiuret (11), and 1,1,3-trimethyl-5-phenylbiuret (13) were found to be more potent than phenylbutazone. The analgesic activity of 7 and of 5-(4-chlorophenyl)-1,1,3-trimethylphenylbiuret (16) is higher than that of aminopyrine.

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Takahiro Yabuuchi

Synthesis of new antimicrobials. IV. Synthesis of alkylenebis-(thiourea) derivatives and their related compounds.

Studies on the Synthesis of New Antimicrobials. I. Synthesis of 2, 5-Dichloroaniline Derivatives and their Some Antibacterial Activities

Studies on Thiophene Derivatives. I. Syntheses of 2-Amino-1, 1-di (2-thienyl) alkanols.

Studies on Thiophene Derivatives. III. Clinical Application of 3-Piperidino-1, 1-di (2-thienyl)-1-butene as a New Antitussive.

Syntheses, Antiinflammatory, and Analgesic Activities of Arylbiurets

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