Combined modality treatment consisting of aromatherapy, footsoak, and reflexology appears to be effective for alleviating fatigue in terminally ill cancer patients. To confirm safety and effectiveness of this combined modality treatment, further investigation including randomized treatment assignment is warranted.

In order to elucidate the hydrogen-bonding behavior of cross-linked resin-bound peptides in the swollen state, conformational properties of cross-linked polystyrene resin bound oligoleucines were studied by infrared spectroscopy. The conformational analysis of H-Leu"-Phe-resins ( = 3, 6, 9, and 15) swollen in methylene chloride revealed that the peptide chains had various conformations depending on the chain length: = 3, essentially an unordered structure; = 6 and 9, mainly the /3-sheet structure; and = 15, predominantly the -helical structure. The formation of the /3-sheet structure indicates that cross-linked resin-bound peptides in the swollen state can easily interact with each other through intermolecular hydrogen bonds even at a low loading of peptide chains and that the intraresin site separation of the peptide chains is not achieved even when the peptide chain length is not so long. Effects of solvent polarity on conformational transformations of H-Leu"-Phe-resins ( = 3, 6, 9, and 15) were also examined. Cross-linking effects on the conformational properties of cross-linked H-Leu"-Phe-resins ( = 3, 6, 9, and 15) were further investigated by comparison with the conformational properties of soluble H-Leu"-Phe-resins ( = 3, 6, 9, and 20).

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