Background: Regulation of neuronal progenitor cell migration is critical for proper brain lamination. Results: G protein-coupled receptor signaling promotes cell migration, lamellipodium formation, and Rac activation by phosphorylating a microtubule-associated protein, doublecortin. Conclusion: Doublecortin is released from microtubules and induces actin reorganization in a phosphorylation-dependent manner. Significance: This is the first evidence for the coordinated regulation of microtubule and actin dynamics.

The results of the present study demonstrate the potential utility of Aspergillus molds as a functionally new microbial resource for industrial applications such as the bleaching of heme proteins. © 2018 Society of Chemical Industry.

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