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It is difficult to compare the effect of all the medicines with the same effect. This is because there is little data in which various medicines carried out the direct comparison mutually, so far. The ethical pharmaceutical has presented various experimental results in order to obtain approval of the Ministry of Health, Labor and Welfare. The information is described in the ethical pharmaceutical package insert. Ethical pharmaceutical package insert is published and anyone can obtain them. It is possible to make a quantitative evaluation of ethical pharmaceutical with ethical pharmaceutical package insert, if we analyze them with text mining method. Therefore, we make an intensive research to estimate the effect of medicine with text mining as an example of analgesics in this paper. As a result, we are succeeding in extracting the difference in the effect of medicines in the form of magnification. However, the fluctuation range of magnification of effect among the extracted medicines was large. Then, this is because the size of this fluctuation range comes from the experimental configuration; we analyzed the effect of magnification of each experimental configuration. As a result, it was suggested that the fluctuation width of an effect decreases. Furthermore, the same result with anti-histamines medicine was also obtained. From this result, it became clear that the experimental configuration has contributed to the effect of the medicine.