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Key words：collagenous colitis, Lansoprazole, hemodialysis 〈Abstract〉 An 81-year-old male on maintenance hemodialysis since December 2008 had been taking various medications including Lansoprazole. The patient developed symptoms of chronic watery diarrhea in March 2009. On colonoscopy, a longitudinal ulcer was noted on the left side of the colon. Biopsy speciments demonstrated thickened subepithelial collagen bands. After discontinuing Lansoprazole, the patientʼs symptom improved. The patientʼs clinical and histological findings were compatible with a diagnosis of Lansoprazole-associated collagenous colitis. Many hemodialysis patients have been administered proton pump inhibitors such as Lansoprazole. If a hemodialysis patients with chronic diarrhea has been taking Lansoprazole, the possibility of collagenous colitis should be considered.

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