Abstract:Our study is the first attempt to study the interaction between NaN3 and hydrated fullerenes C60 by means of a non-chemical reaction-based approach. The aim is to study deviations of signals obtained by 14 N NMR spectroscopy to detect the binding interaction between sodium azide and hydrated fullerene. We considered 14 N NMR spectroscopy as one of the most suitable methods for the characterization of azides to show resonance signals corresponding to the three non-equivalent nitrogen atoms. The results demonstrate that there are changes in the chemical shift positions and line-broadening, which are related to the different molar ratios of NaN 3 :C60 in the samples.

Inhibitory effect of triazole fungicides were evaluated on the human aromatase enzyme and compared with the Letrozole (LTZ), the most potent inhibitor of aromatase, which is used as anti-estrogen for breast cancer treatment. For this study was used software AUTODOCK to calculate inhibition energy (IE) of triazoles on aromatase enzyme CYP19A1. Those compounds with minimal binding energy are safer in terms of toxicity and resistance of other prescription drugs like non-steroid AIs. In our study we found that four triazole fungicides compounds, Triticonazole, Tebuconazole, Metconazole and Fluquinconazole, exhibited minimal inhibition constant (IC). .

15 common fungicides were evaluated to study their inhibitory effects on the human aromatase enzyme in comparison with the Letrozole (LTZ), the most potent inhibitor of aromatase (AI) used as anti-estrogen for breast cancer treatment using AUTODOCK software for calculation of inhibition energy on CYP19A1 aromatase enzyme. Those compounds with minimal binding energy are safer in terms of toxicity and resistance of other prescription drugs like non-steroid AIs. In the authors' study, they found that four triazole fungicides compounds, Triticonazole, Tebuconazole, Metconazole and Fluquinconazole, exhibited minimal inhibition constant (IC).