Metaplastic processes represent the transformation of one type of cell into another type within the same tissue. It belongs to the group of adaptive-compensatory processes that develop in response to changed environmental conditions, hormonal stimulation or the development of inflammatory processes. Because its development is directly or indirectly accompanied by the tumorogenesis, they Georgian Scientists/ . 5 N 2, 2023 287 are considered as a pre-cancer condition with different potential for malignancy. The type of metaplasia depends on the type of target tissue itself. AgNOR/The Nucleolar Organizer Regions stands for Nucleolar Organizer Regions and are loops of DNA that project beneath the nucleolars of mitotic interphase nuclei. Increased amounts of AgNOR are associated with increased cell proliferation. The aim of the study was to evaluate the proliferative activity of different types of metaplasias of the cervix using AgNor technology. Based on the results of our research, we can assume that the mentioned technology can be used in routine practice as an aid to evaluate proliferative activity during cervical metaplastic processes.

Metaplasia represents the replacement of one differentiated cell type with another differentiated cell type, which is frequently seen in uterine cervix, particularly in endocervical epithelium. There are many different types of metaplasia in endocervix. It is suggested that metaplasia represents the fertile soil for the development of neoplasia. However, which cases of metaplasia transform into neoplasia, which type of metaplasia is more realted to neoplastic transformation or if there are some molecular markers which can predict the potential of neoplastic transformation, are nowadays less known. Current review represents the critical discussion of the available literature with regards to the evaluation of molecular markers and the potential of neoplastic transformation in cervical metaplasia.