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Fused pyrrole derivativesFused pyrrole derivatives R 0160 Novel Route for Obtaining Isomeric Benzo[b]thiophenoindoles. -The synthesis of title compounds such as (VI) and (VII) by reduction of the corresponding isatins (IV) and (V), obtained by cyclization of oxime (III) under Sandmeyer reaction conditions, is described. -(TSINTSADZE, T. G.; KHOSHTARIYA, T. E.; KURKOVSKAYA, L. N.; MIRZIASHVILI, N. T.; SIKHARULIDZE, M. I.; Chem. Heterocycl.

Ion channels are parts of the nerve cell membrane that provide the selective permeability of ions, i.e. positively and negatively charged particles, and participate in the regulation of the body's vital processes. They are responsible for regulating the flow of ions in the plasma and membranes of all cells, controlling the intracellular concentrations of various ions. The alternating closing and opening of sodium, potassium and calcium ion channels ensures the spread of the nerve impulse. Blockage of ion channels causes serious changes in the body. In today's medicine, a number of diseases are explained precisely by the malfunction of ion channels. Widespread pathologies in the world population: angina pectoris, arterial hypertension, arrhythmia, epilepsy, diabetes, etc. This is a small list of diseases that are caused by malfunctioning of ion channels in the human body. Based on this, the diseases caused by ion channel malfunctions and the effective remedies for their treatment are an urgent issue for the world population.