Background: E3 ubiquitin ligases facilitate destruction of other proteins. Results: In frog egg extract, the DNA repair factor thymine DNA glycosylase (TDG) was destroyed during DNA replication and repair, dependent on the E3 ubiquitin ligase CRL4 Cdt2 . Conclusion: TDG is a novel target of CRL4 Cdt2 . Significance: We identified a novel form of TDG regulation that informs how cells regulate S phase and epigenetic inheritance.
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