Background:The Warburg effect in cancer is manifested by increased glycolysis and decreased respiration. Our goal was to determine how mitochondria are suppressed in osteosarcoma (OS). Results: OS cells showing the Warburg effect have markers of the mitochondrial permeability transition (MPT). Conclusion:MPT plays a possible role in suppression of mitochondrial function in OS. Significance: Our data implicate the MPT in metabolic reprogramming in cancer.

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