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ABSTRACT:The aim of our study was to establish the relative frequency of biopsy proven tumors of central nervous system (CNS). Two hundred and forty two (242) CNS Biopsy specimens were studied in a one year period. Out of 72 CNS tumors, 66 were primary 4 were metastatic. Among 4 metastatic tumors, the most common histological type is adenocarcinoma. The most frequent type of CNS tumour was astrocytoma followed by meningioma.

ABSTRACT:The spectrum of lesions encountered in the fallopian tube, their age wise incidence and histopathology are studied. Eight hundred and forty cases where fallopian tubes were removed either separately as salpingectomy specimens or along with hysterectomy or as salpingo-ophorectomy specimens were analysed and their histopathological findings were documented. Majority of tubal specimens were normal. There is significant number of chronic nonspecific salpingitis cases. The rare cases in our study are actinomycosis and primary adenocaricnoma.

BACKGROUND AND PURPOSE: Gestational trophoblastic disease (GTD) is a common spectrum of abnormal placental villous trophoblastic proliferation that occurs in women of reproductive age group. The present study is undertaken to discuss about the epidemiology, clinical presentation and pathology diagnosis of each of the trophoblastic disease variants. MATERIALS AND METHODS:The present study included 82 cases of GTD over a period of 3 years. The H&E sections of FFPE tissue were studied. Periodic acid Schiff (PAS) stain was done as an adjuvant in 5 cases of early complete mole. IHC with p57 kip2 was done in 6 cases of complete mole and 6 cases of partial mole. RESULTS: Hydatidiform mole (93.9%) was the most common variant of GTD with peak incidence in 21-30 years age group and more common in primigravida. There were one case of invasive mole, 2 cases of choriocarcinoma and 2 cases of persistent trophoblastic disease. Most patients of GTD were of blood group O followed by group A. Early complete mole, complete mole and partial mole were differentiated by examining H&E sections. Myxoid stroma of early complete mole showed PAS positivity. p57 was negative in all the 6 cases of complete mole. Five cases of partial mole showed positivity, but one case was negative; on review, it was diagnosed as complete mole.CONCLUSION: The study shows the high incidence of molar pregnancies in Indian women and discusses the importance and utility of IHC in hydatidiform mole pathology.

Congenital teratomas represent derivatives of all three germinal cell layers, arranged in varying degree of complexity and they rarely affect the orbit. We report a rare case of unilateral congenital orbital teratoma with marked proptosis presenting at birth.