AIDS patients often display symptom of diarrhea, an indication of hydrogen bonding mediated by viral proteins with amino acids capable of secondary chemical bonding. With hydrogen bonding to protons, local strong acids such as HCl could build up, giving rise to proton stress which may damage cells or trigger tumorigenesis. Weak organic acids counteract strong acids and attenuate proton stress. The integration of antiviral medicine with probiotics could yield favorable outcomes to AIDS patients and meanwhile reduce cancer incidences.

Physical exercises and labor have been confirmed in epidemiological studies that they are beneficial to human health, significantly reducing risks for cardiovascular diseases, cancer, Alzheimer’s disease, etc. Despite the paucity of athletic sudden death, sporadic cases were reported each year in long distance running. Energy metabolism produces protons and organic acids in the limbs, and thus reduces stresses in internal organs. Calcium oxalate was proposed as the causative molecule of heart disease. Intensive exercise or labor can build up dangerous levels of oxalate from the pathways of energy metabolism, posing threat to few susceptible individuals. Pre-exercise or post-exercise oxalate or calcium levels, or constipation can be monitored to predict risks to cardiac arrest or athletic sudden death.

Tangshan earthquake in China occurred with a periodicity of 297 years with focal depth of 11 km. An average of 0.10147 meter of earth crust is uplifted every day. The 9.0 magnitude earthquake was said to occur once every other 1100 years off the northeastern pacific coast of Japan with a focal depth of 20 km. An average of 0.04981 meter of earth’s crust is uplifted daily. These results can be viewed as slope coefficient or potential energy coefficient. Other coefficient such as latitude needs to be incorporated for theoretical calculations.