There is a new world health crisis threatening the public with spread of COVID-19 (Coronavirus Disease-2019). Since 2019 when Covid-19 emerged in Hunan seafood market at Wuhan, South China and rapidly spread throughout the world, the virus outbreak has been declared a public health emergency by the WHO. Corona virus causes respiratory infection including pneumonia, cold, sneezing and coughing while in animal it causes diarrhea and upper respiratory diseases. Corona virus transmitted human to human or human to animal via airborne droplets. Patient shows various symptoms like fever, cough, sore throat, breathlessness and fatigue. The disease is being cured through general treatment, symptomatic treatment and by other methods. This review outlines the Epidemiology, Diagnosis, Management and prevention of this fatal disease. Keywords: Coronavirus disease-2019, COVID-19, Respiratory Syndrome, Symptoms, Prevention, Treatment.

The presence of secondary metabolite biosynthetic gene clusters (BGCs) makes actinobacteria well-known producers of diverse metabolites. These ubiquitous microbes are extensively exploited for their ability to synthesize diverse secondary metabolites. The extent of their ability to synthesize various molecules is yet to be evaluated. Current advancements in genome sequencing, metabolomics, and bioinformatics have provided a plethora of information about the mechanism of synthesis of these bioactive molecules. Accessing the biosynthetic gene cluster responsible for the production of metabolites has always been a challenging assignment. The genomic approach developments have opened a new gateway for examining and manipulating novel antibiotic gene clusters. These advancements have now developed a better understanding of actinobacterial physiology and their genetic regulation for the prolific production of natural products. These new approaches provide a unique opportunity to discover novel bioactive compounds that might replenish antibiotics’ exhausted stock and counter the microbes’ resistance crisis.

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