Background/Context: Strabismus is a condition that results in loss of self esteem and affects quality of life due to the changes it may cause in facial appearance and other factors. There is a dearth of Indian literature on children and adolescents with strabismus. The current study analyzed self esteem and quality of life in children and adolescents with strabismus. Methods: Children and adolescents between 6-17 years attending the ophthalmology out-patient department of a tertiary general hospital and their normal siblings were identified and assessed after parental consent using a semi-structured proforma and the KINDL questionnaire. The results were statistically analyzed and presented. Results: 35 children and adolescents with strabismus were compared to 38 siblings who were the controls. It was seen that children and adolescents with strabismus scored lower on family and social contacts quality of life scores on all subscales of the KINDL questionnaire. However, self-esteem did not differ across both groups. Conclusion: Further larger studies in diverse populations are needed to corroborate the effects of strabismus on self esteem and quality of life.