The removal of the deposited droplets on a solid surface is crucial to considerable practical applications that require self-cleaning properties. In this work, a strategy of cleaning a deposited droplet ("D-droplet") by coalescing with a heterogeneous and easily jumping droplet ("J-droplet") is proposed. Molecular dynamics simulation studies have shown that the coalescence of these two kinds of droplets would not guarantee the removal of D-droplet, unless the lifting ability of J-droplet is enhanced through the reduction of the solid−liquid interaction. However, this is a bad scenario with low efficiency. Further investigation suggests that by introducing two J-droplets to produce triple-coalescence dynamics, the D-droplet could be successfully jumping from the substrates due to the coalescence-induced effect, which is also verified by the free energy calculation. Moreover, the effects of the size of the droplets and the arrangement mode of these three droplets on the jumping dynamics are both considered. The studies not only help advance our understanding of coalescence-induced jumping of heterogeneous droplets, but also open up new ways to remove the deposited impure droplets, which is expected to guide the fields of self-cleaning.