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The distorted X-Ray Image Intensifier (XRII) image can introduce negative effect on following work for C-arm CT imaging system. In this paper, we propose an integrated approach based on least squares and Biharmonic spline interpolation to correct geometric distortions of XRII images. The method first uses morphology operation to extract the coordinate values of control points. Then the least square method fits the extracted coordinate values in every row and computes the more coordinate values by fixing the length in every row. Finally, The Biharmonic spline interpolation is used to interpolate the all coordinate values and correct the distortional XRII image. The experiment shows that the integrated method can effectively correct the distorted XRII image.

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