Objective: The objective of our research is to prepare silver nanoparticles from the rhizome extract of Curcuma caesia and develop topical herbal gel formulation for the effective treatment of acne. Methods: In this present study, silver nanoparticles were synthesized using hydroalcoholic extract of Curcuma caesia rhizome. Silver nanoparticles loaded gels were evaluated for pH, viscosity, spreadability, in vitro release, estimation of total flavonoids and alkaloid content and antibacterial (propioni bacterium acne) studies. Results: The synthesized silver nanoparticles were stable, spherical shape with average particle size of 220.5 nm. The results obtained in the developed formulation showed no lumps, had uniform color dispersion and were free from any fiber and particle. It was also observed to have easy washablity, good spreadability, pH was found to be 6.58±0.02 and 7.02±0.01 similar to pH of the skin. The antibacterial study of the developed formulation showed inhibitory activity against Propioni bacterium acne. Synthesized silver nanoparticle loaded gel displayed drug release of optimized formulation F3 follows the Higuchi kinetic model, and the mechanism is found to be non Fickian/anomalous according to Korsmeyer–Peppas. Silver nanoparticles effectively inhibited the growth of both microorganism indicating good antibacterial properties. Conclusion: Synthesis of silver nanoparticles using Curcuma caesia is a new, green method and not reported yet, as per literature survey done for this project. Successful synthesis and evaluation of silver nanoparticles was proved by the in-vitro study. Keywords: Curcuma caesia, Silver nanoparticles, Propioni bacterium acne, Acne, Flavonoids content, Alkaloid content, Antibacterial.

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Rheumatoid arthritis (RA) is a progressive, chronic, debilitating autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self-neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. Arthritis is not an inherited disease but caused by stimulation of some hidden arthritis susceptible genes lowering the quality of life throughout the world, particularly in developing countries. RA generally affects the joints like wrists, elbows, knees and ankles. Usually women are more affected by RA than men due to the prevalence of hormonal changes. Age is also an important factor that contributes for the development of RA. Several anti-inflammatory and disease-modifying drugs are available for RA therapy. However, the prolonged use of these drugs is associated with severe side effects. Furthermore, these drugs are effective only in a proportion of RA patients. Hence, there is a need to search for new therapeutic agents that are effective yet safe. Interestingly, a variety of herbs and other natural products offer a vast resource for such anti-arthritic agents. Nature has been a source of medicinal agents for more than thousands of years and herbal therapy predominates in traditional systems of medicine as well as in alternative medicine practiced in various cultures such as Indian system of medicine, Chinese Traditional Medicine, Unani classical literature. This review article presents about various polyherbal formulations (PHF) utilized in RA treatment. PHF has been used all around the earth due to its medicinal and therapeutic application. The present review deals with various commercial and non-commercial polyherbal formulation used by different countries of the world for the treatment of RA, their therapeutic potentials including clinical and preclinical results along with their safety and efficacy. This review will facilitate to gain all about the past scientific research and the necessary information about the anti-arthritic activities of polyherbal formulations which will insist the young researchers for future research to protect human beings from RA and may serves as a natural gold for the promotion of mankind.

Nutraceuticals are the pharmaceutically blended products that possess both nutritional as well as the medicinal value. Such aproduct is designed to improve the physicalhealth, fight against day-to-day challenges such as stress, increase longevity, etc. The food products used as nutraceuticals can be categorized as dietary fiber, prebiotics, probiotics, polyunsaturated Fatty acids, antioxidants and other different types of herbal natural foods. These nutraceuticals used in various diseases such as Obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc.. In recent years there Is a growing interest in nutraceuticals which provide health benefits and are alternative to Modern medicine. By using nutraceuticals, it may be possible to reduce or eliminate the need for conventional medications, reducing the chances of any adverse effect. The Nutraceuticals are the best way to boost immunity. The nutraceuticals also plays an important role in economic growth of some developing countries including India.

Liquid dosage forms are generally found in medicines for aged and paediatrics patients. Though, they have specific advantages, along with fast efficacy due to the devoid of dissolution time and quick absorption in the stomach and intestines than tablets. Liquid formulations have been broadly used in pharmaceutics due to their high dosing adjustability, comfort of swallowing, and rapid onset of action.