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The authors have successfully developed a six-primary -color LCD using six-color LEDs. More specifically, a prototype of a six-primary color LCD having a color gamut of 170% or wider than that of conventional techniques has been realized.

The authors have successfully developed a WUXGA LCD monitor that has the world's highest performance level for color gamut and brightness for the number of pixels equal to or greater than UXGA. It provides a color gamut of approximately 150 [%] of conventional CRTs, and further, our monitor assures the high brightness of 600 [cd/m2] or greater. This research was organized in part by the New Energy and Industrial Technology Development Organization, Japan (NEDO).

Background: Angiogenesis is well known to be an important event in the tissue remodeling observed in allergic diseases. Although there is much evidence that quercetin, one of the most abundant dietary flavonoids, exerts anti-allergic effects in both human and experimental animal models of allergic diseases, the action of quercetin on angiogenesis has not been defined. Therefore, in this study, we first examined the action of quercetin on the secretion of angiogenic factors from murine mast cells in vitro. We also examined the action of quercetin on angiogenic factor secretion in the murine allergic rhinitis model in vivo. Methods: Mast cells (1 × 105 cells/mL) sensitized with ovalbumin (OVA)-specific murine IgE were stimulated with 10.0 ng/mL OVA in the presence or the absence of quercetin for 24 h. The concentrations of angiogenic factors, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), tumor necrosis factor-α, IL-6 and IL-8 in the supernatants were examined by ELISA. BALB/c male mice immunized with OVA were challenged intranasally with OVA every other day, starting seven days after the final immunization. These mice were then orally administered quercetin once a day for five days, starting seven days after the final immunization. Clinical symptoms were assessed by counting the number of sneezes and nasal rubbing behaviors during the 10 min period just after OVA nasal provocation. The angiogenic factor concentrations in the nasal lavage fluids obtained 6 h after nasal antigenic provocation were examined by ELISA. Results: Quercetin significantly inhibited the production of angiogenetic factors induced by IgE-dependent mechanisms at 5.0 µM or more. Oral administration of 25.0 mg/kg quercetin into the mice also suppressed the appearance of angiogenetic factors in nasal lavage fluids, along with the attenuation of nasal symptoms. Conclusions: These results strongly suggest that the inhibitory action of quercetin on angiogenic factor secretion may be implicated in the therapeutic action of quercetin on allergic diseases, especially allergic rhinitis.

The authors have successfully improved the six‐primary color LCD using six‐color LEDs which was introduced in SID 2005. Now the prototype has achieved a luminance 150% higher and with less flicker than the former model. This research was organized in part by the New Energy and Industrial Technology Development Organization, Japan (NEDO).