Preface : Hospital patient safety standards which one is Communication, communication give effect to patient safety. Application between communication nurse and patient in class III inpatient room is not yet fully optimized until risk of patient safety incident. Research is aimed to find out efect of  nurse communication with patient satisfacation patient safety incidents risk. Methods: Type of research is quantitative with analytic study and cross sectional design. Total population of research is 292 people that spread to 7 service units. Sample of 58 people used a purposive sampling technique. Instruments used are communication and patient safety incidents risk questionnaires validity test already do. Data analyzed using univariate and bivariate analysis with Chi Square test. Result: From tests are obtained score p = 0,004 result of p value < score α = 0,05 therefore Ho is rejected and Ha is accepted. OR Score as big 5,455 nurse communication not good with patient have risk 5,455 more big to safety incidents risk. Conclusion: There is a efect of nurse communication with patient satisfacation patient safety incidents risk. It is highly suggested for Hospital nurse to improve communication in care provide at inpatient room to prevent of patient safety incident.