No abstract

Matrix metalloproteinases (MMPs) have been implicated in wound healing. To analyze the roles of MMP-9 and MMP-13 in wound healing, we generated full-thickness cutaneous wounds in MMP-9 knockout (KO), MMP-13 KO, MMP-9/13 double KO, and wild-type mice. Macroscopic wound closure was delayed in all of the KO mice, as compared with wild-type mice. The rate of re-epithelialization was significantly delayed in MMP-9 KO and MMP-13 KO mice and remarkably delayed in MMP-9/13 double KO mice, as compared with wild-type mice. Both MMP-9 and MMP-13 were expressed by the leading edges of epidermal cells in wild-type mice, and the migration of keratinocytes was suppressed by treatment with an MMP inhibitor or transfection of small interfering RNAs for MMP-9 or MMP-13, as compared with controls. The vascular density in wound granulation was significantly lower in both MMP-13 KO and MMP-9/13 double KO mice than in wild-type mice. Degradation of connective tissue growth factor in wound tissue was transiently prevented in MMP-13 KO mice. Morphometric analyses demonstrated a reduction in both wound contraction and myofibroblast formation in both MMP-13 KO and MMP-9/13 double KO mice. Proliferation and transforming growth factor-beta1-induced myofibroblast differentiation of dermal fibroblasts from MMP-13 KO mice were decreased, as compared with wild-type dermal fibroblasts. These data suggest that MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in wound healing, while MMP-9 functions in keratinocyte migration.

which are described as BCN(H) and BC 3 N(H), have been prepared by the interaction of acetonitrile with boron trichloride in a hydrogen and nitrogen atmosphere and acrylonitrile with boron trichloride, respectively. X-ray and electron diffraction analyses indicate that these materials have hexagonal structures similar to that of graphite. ESCA spectra and the possible chemical bonds suggest that the ideal structure of BCN is made of the unit structure of BC 2 N + BN, while BC 3 N is composed of BC 3 N + BNC 3 . A BCN(H) plate has a basal-plane conductivity of 1.28 (Ω cm) -1 at room temperature, while a BC 3 N(H) plate has that of 88.5 (Ω cm) -1 . Thermoelectric measurements indicate that both materials behave as p-type semiconductors and a BCN(H) plate has a high Seebeck coefficient of 300 µV/°K at room temperature in air.

No abstract

Abstract. We describe our data collection and results on activity recognition with wearable, coin-sized sensor devices. The devices were attached to four different parts of the body: right thigh and wrist, left wrist and to a necklace on 13 different testees. In this experiment, data was from 17 daily life examples from male and female subjects. Features were calculated from triaxial accelerometer and heart rate data within different sized time windows. The best features were selected with forward-backward sequential search algorithm. Interestingly, acceleration mean values from the necklace were selected as important features. Two classifiers (multilayer perceptrons and kNN classifiers) were tested for activity recognition, and the best result (90.61 % aggregate recognition rate for 4-fold cross validation) was achieved with a kNN classifier.