INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni , who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

Introduction: Upper gastrointestinal bleeding (HDA) is a serious consequence of schistosomiasis mansoni, resulting from the inflammatory process mediated by IL-10. Method: This is a cross-sectional study involving 123 individuals infected with Schistosoma mansoni, after specific treatment, to verify the association between the genetic polymorphism (-C819T) IL-10 and its serum concentrations with HDA. Results: There was no evidence of an association between the (-C819T) IL-10 polymorphism and its serum concentrations with HDA. Conclusions: The IL-10 (-C819T) polymorphism and levels of IL-10were not associated with HDA in this population.

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