The Eséka Greenstone Belt (CRVE) is located in the Nyong Paleoproterozoic unit, Northern edge of the Congo craton, Cameroon. The petrographic, geochemical, and isotopic geochemistry (Sm-Nd) approach of this Nyong complex amphibolites, allowed to highlight three petrographic facies (plagioclastic amphibolites, melanocratic amphibolites and garnet amphibolites), with mineralogical assemblies more or less similar to Hornblende and plagioclase. Fifteen amphibolites samples distributed throughout the CRVE were collected and differentiated into three main facies (garnet, plagioclastic and melanocratic amphibolites). The thin sections were made at the Langfang Rock Detection Technology Services Ltd laboratory in China. The major elements were analysed by X-ray fluorescence (XRF) in South Africa. Isotope geochemical analyses were achieved at the University of Rennes in France. The analyses were carried out following the isotopic dilution method using a multicollector mass spectrometer by thermos-ionization of the Finnigam MAT 262 type to decipher the isotopic composition of samples. Garnet amphibolites are on average richer in silica (47.40 -52.58%) compared to plagioclastic and melanocratic amphibolites. The alkali content is low in melanocratic amphibolites, in particular for K2O (0.13 -0.14%). These metabasites have several common geochemical features such as: the relatively high contents of Y (22.03 -39 ppm), Zr (63.78 -481.99 ppm), Th (0.55 -12.37 ppm), the low content of Ta ( 0.33 -1.20 ppm); a high concentration of compatible elements (5.60%