Background: Scabies is a skin infection that is a result of direct skin to skin contact and is primarily mediated by close and extended contact with scabies infested person. Scabies occurs worldwide among people of all ages, races, genders and social classes and has been identified as a neglected tropical infectious disease. Globally, it affects more than 130 million people at any time. Objective: The aim of the study was to assess prevalence of scabies and associated factors among primary school children in Raya Alamata District, Tigray, Ethiopia, 2017/2018. Methods: A school based cross-sectional study design was conducted among school children in Raya Alamata District from November 2017 to June in 2018. The sampling technique was multi-stage sampling and sample of the 495 students was selected using simple random sampling technique from the schools. The data was collected using observation (clinical investigation), structured questionnaires and check lists. Data entry, cleaning, editing and analysis were done using SPSS statistical software package version 20. Variables with p-value < 0.25 in the binary logistic regression were selected for final analysis; and final significance was determined at p-value < 0.05. Results: There were 64 cases of scabies with a prevalence of 12.93%. The multivariable logistic regression shows that family history of scabies AOR = 4.73 (95% CI; (1.52, 14.69)), sharing cloths with others (AOR = 17.61; 95% CI (4.98, 82.64)), sleeping with scabies ill person (AOR = 3.74 [1.11, 12.62] and sharing of beds with (AOR = 4.45 (1.04, 19.02) were significant variables at p-value < = 0.05. Conclusion: The prevalence of scabies in school children was 12.93% in elementary school children, which is relatively higher compared to other studies which seeks public health attention. Family history of scabies, share cloth with others, sharing of bed to others and Sleeping with scabies ill person was factors related to scabies under adjustment of other variables. This is high burden which seeks public attention.