Background: Particulate Matter (PM) is one of the important components in air pollution that can cause endothelial vascular dysfunction through exacerbation of atherosclerosis and inflammation of the respiratory system. Increased levels of MDA in blood plasma can be an indicator of oxidative stress. Then, macrophages can secrete proinflammatory cytokines will stimulate immune cells and vascular endothelial cells to release inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrotic factor-α (TNF-α). Curcuma longa works by scavenging the active free radicals involved in the peroxidation process. Aims: This study aims to prove that the administration of Curcuma longa can reduce MDA, TNF-α, and IL-6 levels in Rattus novergicus exposed to soot particulates. Methods: The subjects of this study were 30 male rats which were divided into 5 treatment groups with the following: (C0): negative control; (C+): positive control; (T1):Treatment group 2, rats exposed to particulate soot at a concentration of 1064 mg/m3 for 8 hours and given Curcuma longa at a dose of 1 mg/kg bw; (T2): Treatment group 3 was rats exposed to soot particulates at a concentration of 1064 mg/m3 for 8 hours and given Curcuma longa at a dose of 2 mg/kg bw; (T3) :Treatment group 4 was rats exposed to soot particulates at a concentration of 1064 mg/m3 for 8 hours and given Curcuma longa at a dose of 3 mg/kg bw. Giving the Curcuma longa extract orally with a probe every day for 30 days after treatment of exposure to soot. Examination of MDA, TNF-, and IL-6 levels with the ELISA method. Results: The administration of Curcuma longa can reduce MDA while the lowest MDA levels were obtained in the T3 treatment with an average of 1.542 ± 0.231. The results of the description of the lowest levels of TNF-α were obtained in the C-treatment with an average of 55.981 ± 4.689. Then, the lowest levels of IL-6 were obtained in the C-treatment with an average of 2.292±0.461. Conclusion: The results stated that the administration of Curcuma longa could reduce MDA levels, TNF-α, and IL-6 levels. Curcuma longa as an anti-inflammatory and anti-oxidant play an effective role in inhibiting inflammation by decreasing IL-6 cytokine and TNF-α. Curcuma longa can inhibit lipid peroxidation initiated by free radicals then reduce MDA levels.