Background: CD161 expressed by NK cells and T cells interacts with LLT1.Results: LLT1 expression profile reveals LLT1 is induced by pathogens and IFN-␥ and LLT1/CD161 interaction inhibits NK cell functions whereas it costimulates T cells.
Conclusion:The link between LLT1 expression and pathogen stimulation points toward a role in modulating immune responses to pathogens Significance: LLT1/CD161 interaction is relevant in immunity to infection.
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