Laryngeal cancer is a malignancy on larynx that may occur in glottis, supraglottic and subglottic. This malignancy is a second most carcinoma in head and neck area Clinical manifestation such as dysphonia, breathing obstruction, dysphagia, odynophagia, and hemoptysis. Reported a laryngeal cancer with total laryngectomy without neck dissection combined with radiotherapy which has promising result with a good quality of life. a 62-year-old male with supraglottic carcinoma stage III T3N1M0 complaining severe shortness of breath accompanied by voice abnormality like hoarseness and dysphagia. History of tobacco smoking for 42 years, about 10-12 tobacco sticks per day. Follow up observation for the first year show a good quality of life according to EORTC QLQ-C30 version 3. On the second year, the quality of life is getting better and there were an improvement in physical activity, independent self-care, and no sign of recurrency. Total laryngectomy without neck dissection followed by radiotherapy give promising result with good quality of life within 30 months of observation according to EORTC QLQ-C30 version 3.