Penggunaan obat tradisional akan bermanfaat bagi kesehatan apabila digunakan secara tepat. Pengetahuan dan sikap merupakan faktor yang mempengaruhi tindakan pemilihan pengobatan seseorang. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dan sikap terhadap penggunaan obat tradisional di Kelurahan Sukamaju Baru, Kecamatan Tapos, Kota Depok. Jenis penelitian yang digunakan yaitu observasional yang bersifat deskriptif analitik dengan rancangan penelitian potong lintang (cross sectional) menggunakan instrumen penelitian berupa kuesioner. Pengambilan sampel dilakukan dengan teknik purposive sampling terhadap 153 responden dan diperoleh 149 responden yang memenuhi kriteria inklusi dan kriteria eksklusi. Analisis data dilakukan menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa masyarakat yang mempunyai tingkat pengetahuan baik (69,1%), cukup (23,5%), dan kurang (7,4%). Hasil penelitian sikap yaitu 84,6% mempunyai sikap positif dan 15,4% mempunyai sikap negatif. Sebanyak 71,8% masyarakat menggunakan obat tradisional dengan tepat dan 28,2% masyarakat menggunakan obat tradisional tidak tepat. Hasil penelitian menunjukkan ada hubungan yang signifikan antara tingkat pengetahuan terhadap penggunaan obat tradisional (p value = 0,000) dan ada hubungan yang signifikan antara sikap terhadap penggunaan obat tradisional (p value = 0,000). Pengetahuan dan sikap merupakan faktor yang mempengaruhi tindakan pemilihan pengobatan seseorang, termasuk penggunaan obat tradisional.
Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This disease is based on classification related to pancreatic damage in total or partial so that the impact on insulin production. Glucose transporter is a protein that can glucose uptake from outside cell into cell and provides an important role in the body's glucose homeostasis. Glucose transporter-2 (GLUT-2) is found in the pancreas, liver, and kidney. Parameters used are the expression and amount of GLUT-2 density in pancreatic β cells and in hepatocyte cells in normal and diabetic Rat. Used Wistar strain male white rats. An immunohistochemistry (IHC) staining technique was performed to observe the expression of GLUT-2 and the macbiophotonics image J program to determine total density of GLUT-2. GLUT-2 is marked in brown in the cell nucleus surrounded by cytoplasm. The results showed an increased in GLUT-2 expression in hepatocyte cells with a total density of 25,447,052 and a decreased in GLUT-2 expression in pancreatic β cells with a total density of 5,074,544 by Streptozotocin 50 mg/kg BB-Nicotinamide 100 mg/kg BB (STZ-NA) Intraperitonial routes in induced DM rat. STZ-NA induced triggers damage in pancreatic β cells and significantly influences the expression of GLUT-2 protein. High blood glucose levels give different GLUT-2 activity in hepatocyte cells due to the effects of induced agent.
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