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To evaluate residual pituitary GH, GH responses to continuous 1 80-min infusion of increasing doses of GHRH t-29 followed by iv bolus injection of GHRH were studied in 28 hypopituitary patients, 21 of whom had pituitary abnormalities on MRI. Pituitary hypoplasi a, stalk agenesis and ectopic posterior pituitary lobe in 7 patients with isolated GH deficiency (IGHD) and 6 with multiple pituitary hormone deficiencies (group I); isolated hypoplasia in 8 IGHD (group II); normal pituitary gland morphology in 7 IGHD (group Ill). Pituitary volume was not significantly differ&nt in the groups I and II.